Title : A critical evaluation of fasted state simulating gastric fluid (FaSSGF) that contains sodium lauryl sulfate and proposal of a modified recipe.

Pub. Date : 2008 Jan 22

PMID : 17656053






2 Functional Relationships(s)
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1 The aim of this work is to evaluate one of the most commonly used fasted state simulating gastric fluids (FaSSGFs), which contains sodium lauryl sulfate (SLS) (FaSSGF(SLS)), and propose a more appropriate surfactant concentration. Sodium Dodecyl Sulfate aldehyde dehydrogenase 3 family member A2 Homo sapiens
2 Surface tension studies clearly show that the critical micelle concentration (CMC) of SLS in the relevant media (a media whose pH and sodium chloride concentration are representative of physiological conditions) is significantly lower (p<0.05) than 8.67 mM, which is the SLS concentration in FaSSGF(SLS). Sodium Chloride aldehyde dehydrogenase 3 family member A2 Homo sapiens