Pub. Date : 2007 Jun
PMID : 17611393
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bridge linkage role played by CD98hc of anti-tumor drug resistance and cancer metastasis on cisplatin-resistant ovarian cancer cells. | Cisplatin | solute carrier family 3 member 2 | Homo sapiens |
| 2 | P-gp and CD147/CD98hc complex are both found highly expressed on cisplatin resistant ovarian cancer cell line SKOV3/DDP but only slightly expressed on its parent cell SKOV3. | Cisplatin | solute carrier family 3 member 2 | Homo sapiens |
| 3 | RNAi targeting CD98hc or CD147 both reduce their own and P-gp expression as well as cisplatin IC50 of drug-resistant tumor cells. | Cisplatin | solute carrier family 3 member 2 | Homo sapiens |
| 4 | Cloned potential CD98hc promoter region showed promoter activity in luciferase assay under cisplatin pressure. | Cisplatin | solute carrier family 3 member 2 | Homo sapiens |