Title : Small molecule inducers of heat-shock response reduce polyQ-mediated huntingtin aggregation. A possible therapeutic strategy.

Pub. Date : 2007

PMID : 17596719






3 Functional Relationships(s)
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1 Quantitative RT-PCR and SDS-PAGE experiments revealed that 17-DMAG induces expression of the molecular chaperones Hsp40, Hsp70, and Hsp105 in mammalian cells and inhibits the formation of mutant huntingtin aggregates with higher efficiency than 17-AAG or geldanamycin itself. 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1 Homo sapiens
2 Quantitative RT-PCR and SDS-PAGE experiments revealed that 17-DMAG induces expression of the molecular chaperones Hsp40, Hsp70, and Hsp105 in mammalian cells and inhibits the formation of mutant huntingtin aggregates with higher efficiency than 17-AAG or geldanamycin itself. tanespimycin DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1 Homo sapiens
3 Quantitative RT-PCR and SDS-PAGE experiments revealed that 17-DMAG induces expression of the molecular chaperones Hsp40, Hsp70, and Hsp105 in mammalian cells and inhibits the formation of mutant huntingtin aggregates with higher efficiency than 17-AAG or geldanamycin itself. geldanamycin DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1 Homo sapiens