Title : Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes.

Pub. Date : 2007 Oct

PMID : 17554073






2 Functional Relationships(s)
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Protein Name
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1 ASO, but not mismatch control oligonucleotide, -treated animals showed significant reduction in target CTGF expression in the kidney with a concomitant decrease in proteinuria and albuminuria. Oligonucleotides, Antisense cellular communication network factor 2 Mus musculus
2 Treatment with the CTGF ASO for 8 wk reduced serum creatinine and attenuated urinary albuminuria and proteinuria in diabetic db/db mice, a model of type 2 DN. Creatinine cellular communication network factor 2 Mus musculus