Title : Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists.

Pub. Date : 2007 Jun 14

PMID : 17500511






3 Functional Relationships(s)
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1 High-throughput screening of a subset of the J&J compound library containing the carboxylic acid functional group uncovered a bromophenyl derivative as a moderate potent GPR40 agonist. Adenosine Monophosphate free fatty acid receptor 1 Mus musculus
2 High-throughput screening of a subset of the J&J compound library containing the carboxylic acid functional group uncovered a bromophenyl derivative as a moderate potent GPR40 agonist. Carboxylic Acids free fatty acid receptor 1 Mus musculus
3 Our data supports the hypothesis that GPR40 may play an important role in fatty acid-mediated glucose-dependent insulin secretion. Fatty Acids free fatty acid receptor 1 Mus musculus