Title : Chiral Brønsted acid catalyzed enantioselective Mannich-type reaction.

Pub. Date : 2007 May 30

PMID : 17477527






1 Functional Relationships(s)
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1 Mannich-type reaction of ketene silyl acetals with aldimines proceeded catalytically by means of a phosphoric acid diester, derived from (R)-BINOL, as a chiral Bronsted acid to afford beta-amino esters with good diastereoselectivity in favor of the syn isomer and high enantioselectivity (up to 96% ee). ketene synemin Homo sapiens