Title : Chemoattractant action and molecular signaling pathways of Kit ligand on mouse primordial germ cells.

Pub. Date : 2007 Jun 15

PMID : 17467686






1 Functional Relationships(s)
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1 LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one neuropeptide Y receptor Y6 Mus musculus