Title : Advances in targeting drug delivery to glomerular mesangial cells by long circulating cationic liposomes for the treatment of glomerulonephritis.

Pub. Date : 2007 May

PMID : 17372685






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1 PURPOSE: Newly designed polyethylene glycol (PEG)-modified cationic liposomes, containing a novel cationic lipid TRX-20 (3,5-dipentadecyloxybenzamidine hydrochloride), bind specifically to cultured human mesangial cells, and not to endothelial cells. 3,5-dipentadecyloxybenzamidine hydrochloride thioredoxin 1 Rattus norvegicus