Title : Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA.

Pub. Date : 2007 Apr

PMID : 17372356






4 Functional Relationships(s)
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1 Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA. 2-(phosphonomethyl)pentanedioic acid folate hydrolase 1 Homo sapiens
2 Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA. 2-(phosphonomethyl)pentanedioic acid folate hydrolase 1 Homo sapiens
3 Crystal structures were determined of the extracellular part of GCPII (amino-acid residues 44-750) in complex with two potent inhibitors, quisqualate and 2-PMPA (the strongest GCPII inhibitor to date), at resolutions of 3.0 and 2.2 A, respectively. 2-(phosphonomethyl)pentanedioic acid folate hydrolase 1 Homo sapiens
4 Crystal structures were determined of the extracellular part of GCPII (amino-acid residues 44-750) in complex with two potent inhibitors, quisqualate and 2-PMPA (the strongest GCPII inhibitor to date), at resolutions of 3.0 and 2.2 A, respectively. 2-(phosphonomethyl)pentanedioic acid folate hydrolase 1 Homo sapiens