Pub. Date : 2007 Feb 28
PMID : 17329412
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recently, we demonstrated cyclic alterations in GABA(A) receptor (GABA(A)R) subunit composition over the ovarian cycle correlated with fluctuations in progesterone levels. | Progesterone | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 2 | Recently, we demonstrated cyclic alterations in GABA(A) receptor (GABA(A)R) subunit composition over the ovarian cycle correlated with fluctuations in progesterone levels. | Progesterone | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 3 | Progesterone (5 mg/kg, twice daily) upregulates the expression of GABA(A)R delta subunits and enhances the tonic inhibition mediated by these receptors in dentate gyrus granule cells (DGGCs). | Progesterone | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 4 | Neurosteroids can alter GABA(A)R expression on a rapid timescale, because GABA(A)R upregulation can be induced in brain slices maintained in vitro after a short (30 min) treatment with the neurosteroid 3alpha,5alpha-tetrahydrodeoxycorticosterone (THDOC) (100 nM). | 5alpha-tetrahydrodeoxycorticosterone | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 5 | Neurosteroids can alter GABA(A)R expression on a rapid timescale, because GABA(A)R upregulation can be induced in brain slices maintained in vitro after a short (30 min) treatment with the neurosteroid 3alpha,5alpha-tetrahydrodeoxycorticosterone (THDOC) (100 nM). | 5alpha-tetrahydrodeoxycorticosterone | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 6 | Neurosteroids can alter GABA(A)R expression on a rapid timescale, because GABA(A)R upregulation can be induced in brain slices maintained in vitro after a short (30 min) treatment with the neurosteroid 3alpha,5alpha-tetrahydrodeoxycorticosterone (THDOC) (100 nM). | 5alpha-THDOC | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 7 | Neurosteroids can alter GABA(A)R expression on a rapid timescale, because GABA(A)R upregulation can be induced in brain slices maintained in vitro after a short (30 min) treatment with the neurosteroid 3alpha,5alpha-tetrahydrodeoxycorticosterone (THDOC) (100 nM). | 5alpha-THDOC | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 8 | Consistent with these rapid alterations, acute stress, a condition known to quickly raise THDOC levels, within 30 min induces upregulation of GABA(A)R delta subunit expression and increase tonic inhibition in DGGCs. | 5alpha-THDOC | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |