Title : GPR40 is expressed in glucagon producing cells and affects glucagon secretion.

Pub. Date : 2007 Mar 2

PMID : 17214971






3 Functional Relationships(s)
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Compound Name
Protein Name
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1 In-R1-G9 hamster glucagonoma cells respond dose-dependently to linoleic acid stimulation by elevated phosphatidyl inositol hydrolysis and glucagon release and the cells become increasingly responsive to fatty acid stimulation when overexpressing GPR40. Linoleic Acid free fatty acid receptor 1 Mus musculus
2 Isolated mouse islets also secrete glucagon in response to linoleic acid, a response that was abolished by antisense treatment against GPR40. Glucagon free fatty acid receptor 1 Mus musculus
3 Isolated mouse islets also secrete glucagon in response to linoleic acid, a response that was abolished by antisense treatment against GPR40. Linoleic Acid free fatty acid receptor 1 Mus musculus