Title : Molecular mechanism of negative autoregulation of Escherichia coli crp gene.

Pub. Date : 1991 Aug 25

PMID : 1715982






8 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Transcription of the Escherichia coli crp gene encoding cAMP receptor protein (CRP) is negatively regulated by CRP-cAMP complex that binds to a specific site located downstream from the transcription start site. Cyclic AMP catabolite gene activator protein Escherichia coli
2 Transcription of the Escherichia coli crp gene encoding cAMP receptor protein (CRP) is negatively regulated by CRP-cAMP complex that binds to a specific site located downstream from the transcription start site. Cyclic AMP catabolite gene activator protein Escherichia coli
3 Transcription of the Escherichia coli crp gene encoding cAMP receptor protein (CRP) is negatively regulated by CRP-cAMP complex that binds to a specific site located downstream from the transcription start site. Cyclic AMP catabolite gene activator protein Escherichia coli
4 The binding of CRP-cAMP to this site activates transcription from a second divergent overlapping promoter. Cyclic AMP catabolite gene activator protein Escherichia coli
5 We demonstrated that the crp and divergent promoters are reciprocally and coordinately regulated by CRP-cAMP. Cyclic AMP catabolite gene activator protein Escherichia coli
6 We demonstrated that the crp and divergent promoters are reciprocally and coordinately regulated by CRP-cAMP. Cyclic AMP catabolite gene activator protein Escherichia coli
7 Detailed binding studies revealed that CRP-cAMP stimulates the binding of RNA polymerase to the divergent promoter and thus blocks the occupation of the crp promoter by RNA polymerase. Cyclic AMP catabolite gene activator protein Escherichia coli
8 Detailed binding studies revealed that CRP-cAMP stimulates the binding of RNA polymerase to the divergent promoter and thus blocks the occupation of the crp promoter by RNA polymerase. Cyclic AMP catabolite gene activator protein Escherichia coli