Pub. Date : 2007 Feb
PMID : 17110602
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. | Cholesterol | angiopoietin-like 3 | Mus musculus |
| 2 | METHODS AND RESULTS: Angptl3-deficient mice showed low plasma HDL cholesterol and HDL phospholipid (PL), and which were increased by ANGPTL3 supplementation via adenovirus. | Cholesterol | angiopoietin-like 3 | Mus musculus |
| 3 | METHODS AND RESULTS: Angptl3-deficient mice showed low plasma HDL cholesterol and HDL phospholipid (PL), and which were increased by ANGPTL3 supplementation via adenovirus. | Phospholipids | angiopoietin-like 3 | Mus musculus |
| 4 | METHODS AND RESULTS: Angptl3-deficient mice showed low plasma HDL cholesterol and HDL phospholipid (PL), and which were increased by ANGPTL3 supplementation via adenovirus. | Phospholipids | angiopoietin-like 3 | Mus musculus |
| 5 | METHODS AND RESULTS: Angptl3-deficient mice showed low plasma HDL cholesterol and HDL phospholipid (PL), and which were increased by ANGPTL3 supplementation via adenovirus. | Phospholipids | angiopoietin-like 3 | Mus musculus |
| 6 | METHODS AND RESULTS: Angptl3-deficient mice showed low plasma HDL cholesterol and HDL phospholipid (PL), and which were increased by ANGPTL3 supplementation via adenovirus. | Phospholipids | angiopoietin-like 3 | Mus musculus |
| 7 | In vitro, ANGPTL3 inhibited the phospholipase activity of endothelial lipase (EL), which hydrolyzes HDL-PL and hence decreases plasma HDL levels, through a putative heparin-binding site in the N-terminal domain of ANGPTL3. | Heparin | angiopoietin-like 3 | Mus musculus |
| 8 | In vitro, ANGPTL3 inhibited the phospholipase activity of endothelial lipase (EL), which hydrolyzes HDL-PL and hence decreases plasma HDL levels, through a putative heparin-binding site in the N-terminal domain of ANGPTL3. | Heparin | angiopoietin-like 3 | Mus musculus |
| 9 | Post-heparin plasma in Angptl3-knockout mice had higher phospholipase activity than did that in wild-type mice, suggesting that the activity of endogenous EL is elevated in Angptl3-deficient mice. | Heparin | angiopoietin-like 3 | Mus musculus |