Pub. Date : 2006 Dec
PMID : 17082820
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using a polyglutamine (polyQ) disease model, we found that both endogenous PLIC-1 and EPS15 localize to perinuclear aggresomes, and that polyQ enhances their in vivo interaction. | polyglutamine | ubiquilin 1 | Homo sapiens |
| 2 | Using a polyglutamine (polyQ) disease model, we found that both endogenous PLIC-1 and EPS15 localize to perinuclear aggresomes, and that polyQ enhances their in vivo interaction. | polyglutamine | ubiquilin 1 | Homo sapiens |
| 3 | Using a polyglutamine (polyQ) disease model, we found that both endogenous PLIC-1 and EPS15 localize to perinuclear aggresomes, and that polyQ enhances their in vivo interaction. | polyglutamine | ubiquilin 1 | Homo sapiens |
| 4 | In addition, PLIC-1(DeltaUBL) functions as a dominant-negative mutant, blocking both polyQ transport to aggresomes and the association of EPS15 with dispersed aggregates. | polyglutamine | ubiquilin 1 | Homo sapiens |
| 5 | We also show that PLIC-1 is upregulated by arsenite-induced protein misfolding. | arsenite | ubiquilin 1 | Homo sapiens |