Pub. Date : 2007 Jan 1
PMID : 17064916
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | From reporter gene assay (RGA), the compound with a side chain containing N-n-butyl-N-methyl amide (19a) showed pure antagonistic activity (IC(50)=340nM, FI(5)>10,000nM), whereas known AR antagonists showed partial agonistic activities. | n-n-butyl-n-methyl amide | SLAM family member 7 | Homo sapiens |
| 2 | The optimization of 19a led to compound 23 (CH4892280), which showed more potent pure antagonistic activity (IC(50)=190nM, FI(5)>10,000nM). | ch4892280 | SLAM family member 7 | Homo sapiens |