Title : Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors.

Pub. Date : 1991 Mar

PMID : 1705971






4 Functional Relationships(s)
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1 The alpha 2 beta 2 combination was 5-fold more sensitive to nicotine than to acetylcholine, while the alpha 3 beta 2 combination was 17-fold less sensitive to nicotine than to ACh, and the alpha 3 beta 4 combination was equally sensitive to both nicotine and ACh. Acetylcholine MGC75582, possible similarity to act2 S homeolog Xenopus laevis
2 The alpha 2 beta 2, alpha 3 beta 2, and alpha 3 beta 4 combinations were each equally sensitive to DMPP and ACh, while the alpha 2 beta 4, alpha 4 beta 2, and alpha 4 beta 4 combinations were 4-24-fold less sensitive to DMPP than to ACh. 2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide MGC75582, possible similarity to act2 S homeolog Xenopus laevis
3 The alpha 2 beta 2, alpha 3 beta 2, and alpha 3 beta 4 combinations were each equally sensitive to DMPP and ACh, while the alpha 2 beta 4, alpha 4 beta 2, and alpha 4 beta 4 combinations were 4-24-fold less sensitive to DMPP than to ACh. Acetylcholine MGC75582, possible similarity to act2 S homeolog Xenopus laevis
4 The alpha 2 beta 2, alpha 3 beta 2, and alpha 3 beta 4 combinations were each equally sensitive to DMPP and ACh, while the alpha 2 beta 4, alpha 4 beta 2, and alpha 4 beta 4 combinations were 4-24-fold less sensitive to DMPP than to ACh. 2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide MGC75582, possible similarity to act2 S homeolog Xenopus laevis