Pub. Date : 2006 Nov 13
PMID : 16987501
19 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of nitric oxide synthase and ROS-mediated activation of L-type voltage-gated Ca2+ channels in NMDA-induced DPYSL3 degradation. | ros | dihydropyrimidinase like 3 | Homo sapiens |
| 2 | Involvement of nitric oxide synthase and ROS-mediated activation of L-type voltage-gated Ca2+ channels in NMDA-induced DPYSL3 degradation. | N-Methylaspartate | dihydropyrimidinase like 3 | Homo sapiens |
| 3 | Recently, we have shown that in primary cortical neurons (PCN) NMDA and oxidative stress (H(2)O(2)) caused a calpain-dependent cleavage of DPYSL3 (62 kDa) resulting in the appearance of a lower molecular weight form (60 kDa) of DPYSL3. | N-Methylaspartate | dihydropyrimidinase like 3 | Homo sapiens |
| 4 | Recently, we have shown that in primary cortical neurons (PCN) NMDA and oxidative stress (H(2)O(2)) caused a calpain-dependent cleavage of DPYSL3 (62 kDa) resulting in the appearance of a lower molecular weight form (60 kDa) of DPYSL3. | N-Methylaspartate | dihydropyrimidinase like 3 | Homo sapiens |
| 5 | Our preliminary results had shown that antioxidants significantly reduced NMDA-induced DPYSL3 degradation, indicating involvement of ROS in calpain activation. | N-Methylaspartate | dihydropyrimidinase like 3 | Homo sapiens |
| 6 | Our preliminary results had shown that antioxidants significantly reduced NMDA-induced DPYSL3 degradation, indicating involvement of ROS in calpain activation. | ros | dihydropyrimidinase like 3 | Homo sapiens |
| 7 | The aim of this study was to investigate the possible involvement of NOS in NMDA-induced DPYSL3 degradation. | N-Methylaspartate | dihydropyrimidinase like 3 | Homo sapiens |
| 8 | We found that NOS inhibitor (L-NAME) significantly prevented NMDA-induced ROS formation, as well as intracellular Ca(2+) increase [Ca(2+)](i), DPYSL3 degradation and cell death. | NG-Nitroarginine Methyl Ester | dihydropyrimidinase like 3 | Homo sapiens |
| 9 | Further, exposure of PCN to NO donor (SNP) resulted in significant [Ca(2+)](i) increase, ROS generation and probable calpain-mediated DPYSL3 truncation. | PREGNENOLONE CARBONITRILE | dihydropyrimidinase like 3 | Homo sapiens |
| 10 | The NMDA- and oxidative stress (ROS)-induced DPYSL3 truncation was totally dependent on extracellular [Ca(2+)](i). | N-Methylaspartate | dihydropyrimidinase like 3 | Homo sapiens |
| 11 | The NMDA- and oxidative stress (ROS)-induced DPYSL3 truncation was totally dependent on extracellular [Ca(2+)](i). | ros | dihydropyrimidinase like 3 | Homo sapiens |
| 12 | While NMDA-induced DPYSL3 truncation was blocked by both NMDA receptor antagonist (MK801) [Kowara, R., Chen, Q., Milliken, M., Chakravarthy, B., 2005. | N-Methylaspartate | dihydropyrimidinase like 3 | Homo sapiens |
| 13 | While NMDA-induced DPYSL3 truncation was blocked by both NMDA receptor antagonist (MK801) [Kowara, R., Chen, Q., Milliken, M., Chakravarthy, B., 2005. | Dizocilpine Maleate | dihydropyrimidinase like 3 | Homo sapiens |
| 14 | Calpain-mediated degradation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H(2)O(2) toxicity. | N-Methylaspartate | dihydropyrimidinase like 3 | Homo sapiens |
| 15 | Calpain-mediated degradation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H(2)O(2) toxicity. | N-Methylaspartate | dihydropyrimidinase like 3 | Homo sapiens |
| 16 | 95 (2), 466-474] and L-VGCC (nimodipine) inhibitors, H(2)O(2)-induced increase in [Ca(2+)](i), ROS generation and DPYSL3 truncation was blocked only by nimodipine. | Hydrogen Peroxide | dihydropyrimidinase like 3 | Homo sapiens |
| 17 | These results indicate that changes in Ca(2+) homeostasis resulting from ROS-dependent activation of L-VGCC are sufficient to induce probable calpain-mediated DPYSL3 truncation and demonstrate for the first time the role of ROS in the mechanism leading to glutamate-induced calpain activation and DPYSL3 protein degradation. | ros | dihydropyrimidinase like 3 | Homo sapiens |
| 18 | These results indicate that changes in Ca(2+) homeostasis resulting from ROS-dependent activation of L-VGCC are sufficient to induce probable calpain-mediated DPYSL3 truncation and demonstrate for the first time the role of ROS in the mechanism leading to glutamate-induced calpain activation and DPYSL3 protein degradation. | ros | dihydropyrimidinase like 3 | Homo sapiens |
| 19 | These results indicate that changes in Ca(2+) homeostasis resulting from ROS-dependent activation of L-VGCC are sufficient to induce probable calpain-mediated DPYSL3 truncation and demonstrate for the first time the role of ROS in the mechanism leading to glutamate-induced calpain activation and DPYSL3 protein degradation. | Glutamic Acid | dihydropyrimidinase like 3 | Homo sapiens |