Pub. Date : 2006 Nov
PMID : 16936225
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Blocking expression of AHR2 and ARNT1 in zebrafish larvae protects against cardiac toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 2 | To address this question we used morpholino oligonucleotide technology to specifically block the expression of zfAHR2, zfARNT1, zfARNT2, and zfCYP1A, and assessed the previously described effects of TCDD on heart morphology, size, and function in the developing morphants. | Morpholinos | aryl hydrocarbon receptor 2 | Danio rerio |
| 3 | We report that blocking zfAHR2 and zfARNT1 expression provided protection against the TCDD-mediated alteration in heart morphology, reduced cardiac myocyte number, decreased cardiac output and ventricular standstill in zebrafish larvae, while the zfarnt2 and zfcyp1a morpholinos did not block the TCDD-induced cardiac toxicity. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |