Title : The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester.

Pub. Date : 1990 Jun 15

PMID : 1693617






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester. Phorbol Esters coagulation factor III, tissue factor Homo sapiens
2 The mechanism of TF induction in human umbilical vein endothelial cells (HUVEC) was investigated in response to LPS and phorbol 12-myristate 13-O-acetate (PMA). phorbol 12-myristate 13-o-acetate coagulation factor III, tissue factor Homo sapiens
3 The mechanism of TF induction in human umbilical vein endothelial cells (HUVEC) was investigated in response to LPS and phorbol 12-myristate 13-O-acetate (PMA). Tetradecanoylphorbol Acetate coagulation factor III, tissue factor Homo sapiens
4 Northern blot analysis of total RNA from HUVEC showed a rapid rise in TF mRNA levels which was maximal at 2 h and had fallen to low levels by 6 h following both LPS (10 micrograms/ml) and PMA (10 ng/ml) stimulation. Tetradecanoylphorbol Acetate coagulation factor III, tissue factor Homo sapiens
5 Cycloheximide (10 micrograms/ml) alone caused induction of TF mRNA. Cycloheximide coagulation factor III, tissue factor Homo sapiens
6 Treatment of cells previously exposed to LPS for 1 or 4 h with actinomycin D indicated a 12-fold difference in the TF mRNA half-life. Dactinomycin coagulation factor III, tissue factor Homo sapiens