Title : Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission.

Pub. Date : 2006 Aug 23

PMID : 16928864






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 OCT3-like immunoreactivity was observed in ependymal and glial-like cells in the DMH. 1,2-Dimethylhydrazine solute carrier family 22 member 8 Rattus norvegicus
2 Consistent with the pharmacological profile of OCT3, corticosterone, 5-HT, estradiol, and the OCT inhibitor decynium22 dose-dependently inhibited histamine accumulation. Histamine solute carrier family 22 member 8 Rattus norvegicus
3 These data support the hypothesis that corticosterone-induced inhibition of OCT3 mediates stress-induced accumulation of 5-HT in the DMH and suggest that corticosterone may acutely modulate physiological and behavioral responses to stressors by altering serotonergic neurotransmission in this brain region. Corticosterone solute carrier family 22 member 8 Rattus norvegicus
4 These data support the hypothesis that corticosterone-induced inhibition of OCT3 mediates stress-induced accumulation of 5-HT in the DMH and suggest that corticosterone may acutely modulate physiological and behavioral responses to stressors by altering serotonergic neurotransmission in this brain region. 1,2-Dimethylhydrazine solute carrier family 22 member 8 Rattus norvegicus