Title : Contribution of NHE-1 to cell length shortening of normal and failing rabbit cardiac myocytes.

Pub. Date : 2006 Oct

PMID : 16916522






3 Functional Relationships(s)
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1 We conclude that in CO2/HCO3--buffered solutions NHE-1 improved cell length shortening of unstretched normal and HFH myocytes via a pHi-independent mechanism. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide sodium/hydrogen exchanger 1 Oryctolagus cuniculus
2 In HEPES-buffered solutions, increased NHE-1 fluxes (P=0.001, n=14) made HFH resting pHi 0.2+/-0.03 units more alkaline than control (n=27). HEPES sodium/hydrogen exchanger 1 Oryctolagus cuniculus
3 We conclude that in CO2/HCO3--buffered solutions NHE-1 improved cell length shortening of unstretched normal and HFH myocytes via a pHi-independent mechanism. Bicarbonates sodium/hydrogen exchanger 1 Oryctolagus cuniculus