Title : Platelet-activating factor stimulation of tyrosine kinase and its relationship to phospholipase C in rabbit platelets: studies with genistein and monoclonal antibody to phosphotyrosine.

Pub. Date : 1990 Apr

PMID : 1691437






8 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PLC-mediated production of radioactive inositol monophosphate, inositol diphosphate, and inositol triphosphate was monitored. radioactive inositol monophosphate LOC100009319 Oryctolagus cuniculus
2 PLC-mediated production of radioactive inositol monophosphate, inositol diphosphate, and inositol triphosphate was monitored. inositol diphosphate LOC100009319 Oryctolagus cuniculus
3 PLC-mediated production of radioactive inositol monophosphate, inositol diphosphate, and inositol triphosphate was monitored. Inositol triphosphate LOC100009319 Oryctolagus cuniculus
4 PAF alone caused stimulation of PLC activity [( 3H]inositol triphosphate production), whereas pretreatment with Genistein (0.5 mM) diminished PAF-stimulated PLC activity to basal level. Platelet Activating Factor LOC100009319 Oryctolagus cuniculus
5 PAF alone caused stimulation of PLC activity [( 3H]inositol triphosphate production), whereas pretreatment with Genistein (0.5 mM) diminished PAF-stimulated PLC activity to basal level. ( 3h]inositol triphosphate LOC100009319 Oryctolagus cuniculus
6 PAF alone caused stimulation of PLC activity [( 3H]inositol triphosphate production), whereas pretreatment with Genistein (0.5 mM) diminished PAF-stimulated PLC activity to basal level. Genistein LOC100009319 Oryctolagus cuniculus
7 PAF alone caused stimulation of PLC activity [( 3H]inositol triphosphate production), whereas pretreatment with Genistein (0.5 mM) diminished PAF-stimulated PLC activity to basal level. Platelet Activating Factor LOC100009319 Oryctolagus cuniculus
8 The above results suggested that Genistein inhibited tyrosine kinase at an early stage of signal transduction by inhibiting PLC. Genistein LOC100009319 Oryctolagus cuniculus