Pub. Date : 2006 Nov
PMID : 16896058
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mercury abolishes neurotrophic factor-stimulated Jak-STAT signaling in nerve cells by oxidative stress. | Mercury | Janus kinase 3 | Gallus gallus |
| 2 | We found that divalent mercury (HgCl(2)) inhibited ciliary neurotrophic factor and interferon-gamma receptor-mediated Janus tyrosine kinase (Jak)/signal transducers and activators of transcription (STAT) pathway activation in SK-N-BE(2)-C neuroblastoma cell cultures, but did not inhibit the fibroblast growth factor receptor tyrosine kinase. | Mercury | Janus kinase 3 | Gallus gallus |
| 3 | We found that divalent mercury (HgCl(2)) inhibited ciliary neurotrophic factor and interferon-gamma receptor-mediated Janus tyrosine kinase (Jak)/signal transducers and activators of transcription (STAT) pathway activation in SK-N-BE(2)-C neuroblastoma cell cultures, but did not inhibit the fibroblast growth factor receptor tyrosine kinase. | Mercury | Janus kinase 3 | Gallus gallus |
| 4 | The specific inhibition of growth factor-mediated Jak-STAT signaling pathways in neurons by HgCl(2)-induced oxidative stress offers a new mechanism by which mercury may produce neurotoxic symptoms in the developing nervous system, promote neurodegeneration in mature neurons, and inhibit recovery following neurotrauma. | Mercuric Chloride | Janus kinase 3 | Gallus gallus |
| 5 | The specific inhibition of growth factor-mediated Jak-STAT signaling pathways in neurons by HgCl(2)-induced oxidative stress offers a new mechanism by which mercury may produce neurotoxic symptoms in the developing nervous system, promote neurodegeneration in mature neurons, and inhibit recovery following neurotrauma. | Mercury | Janus kinase 3 | Gallus gallus |