Title : Extended application of a chiral stationary phase based on (+)-(1 8-crown-6)-2,3,11,12-tetracarboxylic acid to the resolution of N-(substituted benzoyl)-alpha-amino acid amides.

Pub. Date : 2006 Jul

PMID : 16894785






11 Functional Relationships(s)
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1 A chiral stationary phase (CSP 1) based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid was applied to the resolution of N-(substituted benzoyl)-alpha-amino acid amides and esters. 18-crown-6 2,3,11,12-tetracarboxylic acid regulator of calcineurin 1 Homo sapiens
2 A chiral stationary phase (CSP 1) based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid was applied to the resolution of N-(substituted benzoyl)-alpha-amino acid amides and esters. n-(substituted benzoyl)-alpha-amino acid amides regulator of calcineurin 1 Homo sapiens
3 A chiral stationary phase (CSP 1) based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid was applied to the resolution of N-(substituted benzoyl)-alpha-amino acid amides and esters. Esters regulator of calcineurin 1 Homo sapiens
4 Among the substituents on the benzoyl group of analytes, the nitro group was the best for good resolution of analytes on CSP 1. nitro regulator of calcineurin 1 Homo sapiens
5 From these results, the two N-H hydrogens of the amide tethers of CSP 1, the carbonyl oxygen of the amide group of analytes, and the nitro group on the benzoyl group of analytes were concluded to play significant roles in chiral recognition. Nitrogen regulator of calcineurin 1 Homo sapiens
6 From these results, the two N-H hydrogens of the amide tethers of CSP 1, the carbonyl oxygen of the amide group of analytes, and the nitro group on the benzoyl group of analytes were concluded to play significant roles in chiral recognition. Hydrogen regulator of calcineurin 1 Homo sapiens
7 From these results, the two N-H hydrogens of the amide tethers of CSP 1, the carbonyl oxygen of the amide group of analytes, and the nitro group on the benzoyl group of analytes were concluded to play significant roles in chiral recognition. Amides regulator of calcineurin 1 Homo sapiens
8 From these results, the two N-H hydrogens of the amide tethers of CSP 1, the carbonyl oxygen of the amide group of analytes, and the nitro group on the benzoyl group of analytes were concluded to play significant roles in chiral recognition. Amides regulator of calcineurin 1 Homo sapiens
9 In addition, various N-(3,5-dinitrobenzoyl)leucine amides with different lengths of N-alkylamide chains were resolved on CSP 1 and N-(3,5-dinitrobenzoyl) leucine N-propylamide was found to show the best chiral recognition in terms of the separation (alpha = 1.30) and the resolution factor (Rs= 3.17). n-(3,5-dinitrobenzoyl)leucine amides regulator of calcineurin 1 Homo sapiens
10 In addition, various N-(3,5-dinitrobenzoyl)leucine amides with different lengths of N-alkylamide chains were resolved on CSP 1 and N-(3,5-dinitrobenzoyl) leucine N-propylamide was found to show the best chiral recognition in terms of the separation (alpha = 1.30) and the resolution factor (Rs= 3.17). n-alkylamide regulator of calcineurin 1 Homo sapiens
11 In addition, various N-(3,5-dinitrobenzoyl)leucine amides with different lengths of N-alkylamide chains were resolved on CSP 1 and N-(3,5-dinitrobenzoyl) leucine N-propylamide was found to show the best chiral recognition in terms of the separation (alpha = 1.30) and the resolution factor (Rs= 3.17). n-(3,5-dinitrobenzoyl) leucine n-propylamide regulator of calcineurin 1 Homo sapiens