Pub. Date : 1991 Oct
PMID : 1685175
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antimicrobial activities of piperacillin alone and in combination with tazobactam against beta-lactamase-producing bacteria. | Tazobactam | beta-lactamase | Escherichia coli |
| 2 | Tazobactam (YTR 830), a new beta-lactamase inhibitor, was evaluated for its effect in combination with piperacillin, a broad spectrum, but beta-lactamase sensitive, penicillin, against 14 common bacteria. | Tazobactam | beta-lactamase | Escherichia coli |
| 3 | For the beta-lactamase producers, tazobactam decreased the MICs of piperacillin prominently in methicillin-resistant Staphylococcus aureus, Neisseria gonorrhoeae, Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Morganella morganii, Salmonella species and Bacteroides fragilis, with a 4-fold or greater decrease in MIC50, MIC90 and the geometric mean of MIC. | Tazobactam | beta-lactamase | Staphylococcus aureus |
| 4 | We conclude that tazobactam is an effective beta-lactamase inhibitor for increasing the antimicrobial activity of piperacillin against beta-lactamase producing strains of many species of bacteria. | Tazobactam | beta-lactamase | Escherichia coli |
| 5 | We conclude that tazobactam is an effective beta-lactamase inhibitor for increasing the antimicrobial activity of piperacillin against beta-lactamase producing strains of many species of bacteria. | Tazobactam | beta-lactamase | Escherichia coli |