Pub. Date : 1991 Oct 25
PMID : 1682879
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The expression of murine Hox-2 genes is dependent on the differentiation pathway and displays a collinear sensitivity to retinoic acid in F9 cells and Xenopus embryos. | Tretinoin | homeobox B cluster | Mus musculus |
| 2 | In this paper we describe experiments that detail the response of murine Hox-2 genes to cellular differentiation and retinoic acid in cell culture. | Tretinoin | homeobox B cluster | Mus musculus |
| 3 | Hox-2 genes are transiently activated in differentiating ES cells even in the absence of retinoic acid (RA), indicating that their induction is a normal aspect of differentiation. | Tretinoin | homeobox B cluster | Mus musculus |
| 4 | Hox-2 genes are transiently activated in differentiating ES cells even in the absence of retinoic acid (RA), indicating that their induction is a normal aspect of differentiation. | Tretinoin | homeobox B cluster | Mus musculus |
| 5 | Therefore RA exerts its effects on Hox-2 expression by upregulating or modulating genes which are already active, rather than by turning-on silent genes. | Tretinoin | homeobox B cluster | Mus musculus |
| 6 | Together these findings suggest that the collinear response to RA is highly conserved in vertebrates and combined with the ability of RA to modify expression during cellular differentiation could be an important feature of the Hox-2 cluster itself used to generate the spatially-restricted patterns of gene expression in embryogenesis. | Tretinoin | homeobox B cluster | Mus musculus |
| 7 | Together these findings suggest that the collinear response to RA is highly conserved in vertebrates and combined with the ability of RA to modify expression during cellular differentiation could be an important feature of the Hox-2 cluster itself used to generate the spatially-restricted patterns of gene expression in embryogenesis. | Tretinoin | homeobox B cluster | Mus musculus |