Pub. Date : 2006 Jun
PMID : 16800929
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [ERK pathway change in the differentiation of human MDS cell lines SKM-1 induced by sodium butyrate]. | Butyric Acid | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |
| 2 | The study was purposed to investigate the role of extracellular signal-regulated kinase (ERK) pathway in the differentiation of human MDS cell lines SKM-1 induced by sodium butyrate (NaB), and to elucidate the molecular mechanism of differentiation in SKM-1 cells induced by NaB. | Butyric Acid | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |
| 3 | The study was purposed to investigate the role of extracellular signal-regulated kinase (ERK) pathway in the differentiation of human MDS cell lines SKM-1 induced by sodium butyrate (NaB), and to elucidate the molecular mechanism of differentiation in SKM-1 cells induced by NaB. | nab | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |
| 4 | The study was purposed to investigate the role of extracellular signal-regulated kinase (ERK) pathway in the differentiation of human MDS cell lines SKM-1 induced by sodium butyrate (NaB), and to elucidate the molecular mechanism of differentiation in SKM-1 cells induced by NaB. | nab | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |
| 5 | The effect of NaB in combination with the ERK inhibitor PD98059 on the proliferation/differentiation of SKM-1 cells was studied, and then the expression levels of the P21 and HDAC protein were detected by Western blot. | nab | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |
| 6 | The effect of NaB in combination with the ERK inhibitor PD98059 on the proliferation/differentiation of SKM-1 cells was studied, and then the expression levels of the P21 and HDAC protein were detected by Western blot. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |
| 7 | NaB or combination of the MEK inhibitor PD98059 with NaB could increase the differentiation of the SKM-1 cells and up-regulated the levels of the P21 and HDAC protein, but the effect of combination of NaB with PD98059 was higher than that of NaB alone. | nab | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |
| 8 | NaB or combination of the MEK inhibitor PD98059 with NaB could increase the differentiation of the SKM-1 cells and up-regulated the levels of the P21 and HDAC protein, but the effect of combination of NaB with PD98059 was higher than that of NaB alone. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |
| 9 | NaB or combination of the MEK inhibitor PD98059 with NaB could increase the differentiation of the SKM-1 cells and up-regulated the levels of the P21 and HDAC protein, but the effect of combination of NaB with PD98059 was higher than that of NaB alone. | nab | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |
| 10 | NaB or combination of the MEK inhibitor PD98059 with NaB could increase the differentiation of the SKM-1 cells and up-regulated the levels of the P21 and HDAC protein, but the effect of combination of NaB with PD98059 was higher than that of NaB alone. | nab | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |
| 11 | NaB or combination of the MEK inhibitor PD98059 with NaB could increase the differentiation of the SKM-1 cells and up-regulated the levels of the P21 and HDAC protein, but the effect of combination of NaB with PD98059 was higher than that of NaB alone. | nab | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |
| 12 | It is concluded that the inhibition of ERK may be involved in sodium butyrate inducing differentiation in SKM-1 cells. | Butyric Acid | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |