Pub. Date : 1991
PMID : 1668832
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The gene for the androgen receptor (AR) in the androgen-sensitive human prostate cancer cell line LNCaP has a single-base mutation that produces a threonine to alanine change in the androgen-binding domain. | Threonine | androgen receptor | Homo sapiens |
2 | The gene for the androgen receptor (AR) in the androgen-sensitive human prostate cancer cell line LNCaP has a single-base mutation that produces a threonine to alanine change in the androgen-binding domain. | Threonine | androgen receptor | Homo sapiens |
3 | The gene for the androgen receptor (AR) in the androgen-sensitive human prostate cancer cell line LNCaP has a single-base mutation that produces a threonine to alanine change in the androgen-binding domain. | Alanine | androgen receptor | Homo sapiens |
4 | The gene for the androgen receptor (AR) in the androgen-sensitive human prostate cancer cell line LNCaP has a single-base mutation that produces a threonine to alanine change in the androgen-binding domain. | Alanine | androgen receptor | Homo sapiens |
5 | In PC-3 cells expressing LNCaP AR, however, CAT activity was also induced by progestins and the antiandrogen hydroxyflutamide, which had little activity in cells expressing normal AR. | hydroxyflutamide | androgen receptor | Homo sapiens |
6 | In PC-3 cells expressing LNCaP AR, however, CAT activity was also induced by progestins and the antiandrogen hydroxyflutamide, which had little activity in cells expressing normal AR. | hydroxyflutamide | androgen receptor | Homo sapiens |
7 | Steroid-binding competition assays using in vitro synthesized ARs showed that LNCaP AR had a higher affinity than normal AR for progestins, 17 beta-estradiol, and hydroxyflutamide. | Steroids | androgen receptor | Homo sapiens |
8 | Steroid-binding competition assays using in vitro synthesized ARs showed that LNCaP AR had a higher affinity than normal AR for progestins, 17 beta-estradiol, and hydroxyflutamide. | Steroids | androgen receptor | Homo sapiens |
9 | Steroid-binding competition assays using in vitro synthesized ARs showed that LNCaP AR had a higher affinity than normal AR for progestins, 17 beta-estradiol, and hydroxyflutamide. | Estradiol | androgen receptor | Homo sapiens |
10 | Steroid-binding competition assays using in vitro synthesized ARs showed that LNCaP AR had a higher affinity than normal AR for progestins, 17 beta-estradiol, and hydroxyflutamide. | Estradiol | androgen receptor | Homo sapiens |
11 | Steroid-binding competition assays using in vitro synthesized ARs showed that LNCaP AR had a higher affinity than normal AR for progestins, 17 beta-estradiol, and hydroxyflutamide. | hydroxyflutamide | androgen receptor | Homo sapiens |
12 | Steroid-binding competition assays using in vitro synthesized ARs showed that LNCaP AR had a higher affinity than normal AR for progestins, 17 beta-estradiol, and hydroxyflutamide. | hydroxyflutamide | androgen receptor | Homo sapiens |
13 | The antiprogestin and antiglucocorticoid RU 38486 induced CAT activity in PC-3 cells expressing normal AR but not LNCaP AR. | Mifepristone | androgen receptor | Homo sapiens |
14 | These studies indicate that AR mutations may be very important in determining the appropriate method of treatment with steroid hormones or their antagonists. | Steroids | androgen receptor | Homo sapiens |