Title : [Presynaptic regulation of co-release of neuropeptide Y and noradrenaline induced by electrical stimulation of the sympathetic nerve in guinea pig heart].

Pub. Date : 1991 Oct

PMID : 1665390






7 Functional Relationships(s)
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1 Electrical stimulation of the left stellate ganglion (4, 8, 12 and 50 Hz) evoked a calcium-dependent and frequency-related overflow of noradrenaline and NPY. Calcium pro-neuropeptide Y Cavia porcellus
2 When two subsequent stimulations were performed in the same heart, adding exogenous noradrenaline before the second stimulation reduced NPY overflow on the contrary, and NPY decreased the overflow of noradrenaline. Norepinephrine pro-neuropeptide Y Cavia porcellus
3 When two subsequent stimulations were performed in the same heart, adding exogenous noradrenaline before the second stimulation reduced NPY overflow on the contrary, and NPY decreased the overflow of noradrenaline. Norepinephrine pro-neuropeptide Y Cavia porcellus
4 The stimulated release of noradrenaline and NPY was increased by the alpha 2-adrenergic receptor antagonist yohimbine, and attenuated by the alpha 2-adrenergic receptor agonist B-HT 920, respectively. Yohimbine pro-neuropeptide Y Cavia porcellus
5 The adenosine analogue cyclohexyladenosine significantly reduced co-release of noradrenaline and NPY. Adenosine pro-neuropeptide Y Cavia porcellus
6 The adenosine analogue cyclohexyladenosine significantly reduced co-release of noradrenaline and NPY. cyclohexyladenosine pro-neuropeptide Y Cavia porcellus
7 We concluded that electrical stimulation can induce calcium-dependent co-release of noradrenaline and NPY, and this co-release of both transmitters is modulated by presynaptic alpha 2-adrenoceptors. Calcium pro-neuropeptide Y Cavia porcellus