Pub. Date : 2006 Jun 9
PMID : 16631597
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | cAMP differentially regulates gamma-globin gene expression in erythroleukemic cells and primary erythroblasts through c-Myb expression. | Cyclic AMP | hemoglobin subunit gamma 1 | Homo sapiens |
| 2 | Our previous studies demonstrated roles of cyclic nucleotides in gamma-globin gene expression. | Nucleotides, Cyclic | hemoglobin subunit gamma 1 | Homo sapiens |
| 3 | We recently found that, upon activation of the cAMP pathway, expression of the gamma-globin gene is inhibited in K562 cells but induced in adult erythroblasts. | Cyclic AMP | hemoglobin subunit gamma 1 | Homo sapiens |
| 4 | Here we show that c-Myb, a proto-oncogene product that plays a role in cell growth and differentiation, is involved in the cAMP-mediated differential regulation of gamma-globin gene expression in K562 cells and primary erythroblasts. | Cyclic AMP | hemoglobin subunit gamma 1 | Homo sapiens |
| 5 | Together, these results show that the cAMP pathway blocks gamma-globin gene expression in K562 cells by increasing c-Myb expression and c-Myb plays a role in defining the mode of response of the gamma-globin gene to fetal hemoglobin inducers in erythroid cells. | Cyclic AMP | hemoglobin subunit gamma 1 | Homo sapiens |
| 6 | Together, these results show that the cAMP pathway blocks gamma-globin gene expression in K562 cells by increasing c-Myb expression and c-Myb plays a role in defining the mode of response of the gamma-globin gene to fetal hemoglobin inducers in erythroid cells. | Cyclic AMP | hemoglobin subunit gamma 1 | Homo sapiens |