Title : Mitotic defects in XRCC3 variants T241M and D213N and their relation to cancer susceptibility.

Pub. Date : 2006 Apr 1

PMID : 16505003






3 Functional Relationships(s)
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1 However, in contrast to mutations in BRCA1 and BRCA2, the XRCC3(T241M) protein is proficient in homologous recombination and reverts sensitivity to mitomycin C found in XRCC3-deficient cells, whereas XRCC3(D213N) is defective in homologous recombination. Mitomycin X-ray repair cross complementing 3 Homo sapiens
2 However, in contrast to mutations in BRCA1 and BRCA2, the XRCC3(T241M) protein is proficient in homologous recombination and reverts sensitivity to mitomycin C found in XRCC3-deficient cells, whereas XRCC3(D213N) is defective in homologous recombination. Mitomycin X-ray repair cross complementing 3 Homo sapiens
3 However, in contrast to mutations in BRCA1 and BRCA2, the XRCC3(T241M) protein is proficient in homologous recombination and reverts sensitivity to mitomycin C found in XRCC3-deficient cells, whereas XRCC3(D213N) is defective in homologous recombination. Mitomycin X-ray repair cross complementing 3 Homo sapiens