Pub. Date : 2006 Jul 13
PMID : 16501607
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p14ARF promotes RB accumulation through inhibition of its Tip60-dependent acetylation. | Rubidium | lysine acetyltransferase 5 | Homo sapiens |
| 2 | Looking for the mechanisms involved in this process, we demonstrate that the histone acetyl transferase Tip60 directly interacts with RB and stimulates its degradation by the proteasome through acetylation of its C-terminus. | Rubidium | lysine acetyltransferase 5 | Homo sapiens |
| 3 | Furthermore, and consistent with p14ARF-induced RB accumulation, we provide evidence that p14ARF prevents Tip60-mediated RB acetylation, therefore precluding its proteasomal degradation. | Rubidium | lysine acetyltransferase 5 | Homo sapiens |