Title : Molecular determinants of HERG channel block.

Pub. Date : 2006 May

PMID : 16474003






1 Functional Relationships(s)
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1 Here, we characterized the molecular mechanism of hERG block by two low-potency drugs (Nifekalant and bepridil) and two high-potency drugs 1-[2-(6-methyl-2pyridyl)ethyl]-4-(4-methylsulfonyl aminobenzoyl)piperidine (E-4031) and dofetilide). E 4031 ETS transcription factor ERG Homo sapiens