Pub. Date : 2006 Jan
PMID : 16338963
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin E2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3. | Dinoprostone | solute carrier family 22 member 8 | Rattus norvegicus |
| 2 | The major route of PGE2 excretion is via the renal proximal tubular organic anion secretory system, where basolateral uptake that is mediated by renal organic anion transporter 1 (rOAT1) and rOAT3 is rate limiting. | Dinoprostone | solute carrier family 22 member 8 | Rattus norvegicus |
| 3 | Therefore, it was hypothesized that PGE2 itself will abolish its excretion by rOAT1 or rOAT3. | Dinoprostone | solute carrier family 22 member 8 | Rattus norvegicus |
| 4 | In addition, PGE2 diminishes expression of both rOAT1 and rOAT3. | Dinoprostone | solute carrier family 22 member 8 | Rattus norvegicus |
| 5 | Both organic anion uptake and expression of rOAT1 and rOAT3 are dose-dependently downregulated by PGE2. | Dinoprostone | solute carrier family 22 member 8 | Rattus norvegicus |