Title : Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess.

Pub. Date : 2005 Oct

PMID : 16181429






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Aquaporin-4 (AQP4) is a water channel expressed in astroglia at the blood-brain and brain-CSF barriers. Water aquaporin 4 Mus musculus
2 Aquaporin-4 (AQP4) is a water channel expressed in astroglia at the blood-brain and brain-CSF barriers. Water aquaporin 4 Mus musculus
3 However, at 3 days the AQP4 null mice had significantly higher intracranial pressure (mean +/- SEM 27 +/- 2 vs. 17 +/- 2 mmHg; p < 0.001) and brain water content (81.0 +/- 0.3 vs. 79.3 +/- 0.5 % water by weight in the abscess-containing hemisphere; p < 0.01) than wild-type mice. Water aquaporin 4 Mus musculus
4 However, at 3 days the AQP4 null mice had significantly higher intracranial pressure (mean +/- SEM 27 +/- 2 vs. 17 +/- 2 mmHg; p < 0.001) and brain water content (81.0 +/- 0.3 vs. 79.3 +/- 0.5 % water by weight in the abscess-containing hemisphere; p < 0.01) than wild-type mice. Water aquaporin 4 Mus musculus