Title : Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells.

Pub. Date : 2006 Feb

PMID : 16155089






3 Functional Relationships(s)
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1 Thus, in these iNOS-transfected bPAEC, the transfected iNOS and native arginase compete for a common intracellular pool of L-Arg. Arginine nitric oxide synthase 2 Bos taurus
2 Thus, in these iNOS-transfected bPAEC, the transfected iNOS and native arginase compete for a common intracellular pool of L-Arg. Arginine nitric oxide synthase 2 Bos taurus
3 These findings suggest that the use of iNOS gene therapy for pulmonary hypertensive disorders may not only be beneficial through NO-mediated pulmonary vasodilation but also may decrease vascular remodeling by limiting L-Orn production by native arginase. Ornithine nitric oxide synthase 2 Bos taurus