Title : Site-directed mutagenesis of cysteine residues of large neutral amino acid transporter LAT1.

Pub. Date : 2005 Sep 15

PMID : 16125134






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 LAT1 forms a heterodimer with the 4F2hc heavy chain, which are joined by a disulfide bond between Cys160 of LAT1 and Cys110 of 4F2hc. Disulfides solute carrier family 3 member 2 Homo sapiens
2 LAT1 forms a heterodimer with the 4F2hc heavy chain, which are joined by a disulfide bond between Cys160 of LAT1 and Cys110 of 4F2hc. Disulfides solute carrier family 3 member 2 Homo sapiens
3 The present studies use site-directed mutagenesis to convert each of the 12 cysteines of LAT1 and each of the 2 cysteines of 4F2hc into serine residues. Cysteine solute carrier family 3 member 2 Homo sapiens
4 The present studies use site-directed mutagenesis to convert each of the 12 cysteines of LAT1 and each of the 2 cysteines of 4F2hc into serine residues. Serine solute carrier family 3 member 2 Homo sapiens
5 Mutation of the cysteine residues of the 4F2hc heavy chain of the hetero-dimeric transporter did not affect transporter activity. Cysteine solute carrier family 3 member 2 Homo sapiens