Pub. Date : 2005
PMID : 16089297
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FIP1L1-PDGFR alpha is a novel therapeutic target of the kinase inhibitor imatinib (Glivec, Novartis), which provides the basis for the treatment of these patients with this drug. | Imatinib Mesylate | factor interacting with PAPOLA and CPSF1 | Homo sapiens |
| 2 | FIP1L1-PDGFRA positive CEL patients respond very well to imatinib therapy, some of which are remarkable responses with normalization of the blood counts within 2 weeks after start of the therapy. | Imatinib Mesylate | factor interacting with PAPOLA and CPSF1 | Homo sapiens |
| 3 | All imatinib treated FIP1L1-PDGFRA positive CEL patients achieve hematological and cytogenetic remission, and the majority of patients also achieve a molecular remission with the fusion gene no longer detectable in blood, even by the most sensitive PCR techniques. | Imatinib Mesylate | factor interacting with PAPOLA and CPSF1 | Homo sapiens |