Title : Regulation of the functional expression of hexose transporter GLUT-1 by glucose in murine fibroblasts: role of lysosomal degradation.

Pub. Date : 1992 Jun 16

PMID : 1606164






2 Functional Relationships(s)
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1 The acidotropic amines chloroquine (20 microM) and ammonium chloride (10 mM) cause accumulation (both approximately 4-fold) of GLUT-1 protein and a small increase (both approximately 25%) in hexose transport in glucose-fed fibroblasts (24 h). Chloroquine solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus
2 In contrast, chloroquine or leupeptin diminish the reversal by glucose refeeding of the glucose deprivation induced accumulation of GLUT-1 protein but fail to alter the return of hexose transport to control levels. Chloroquine solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus