Title : Evidence for the existence of P2Y1,2,4 receptor subtypes in HEK-293 cells: reactivation of P2Y1 receptors after repetitive agonist application.

Pub. Date : 2005 Jun

PMID : 16025270






2 Functional Relationships(s)
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1 Whereas the P2Y1 receptor-selective antagonist 2"-deoxy-N6-methyladenosine 3",5"-diphosphate (MRS 2179) abolished the responses to ADPbetaS, it decreased and did not alter the responses to ATP and UTP respectively. adenosine 5'-O-(2-thiodiphosphate) purinergic receptor P2Y1 Homo sapiens
2 Although the P2Y1/P2Y4 receptor-preferential antagonist pyridoxalphosphate-6-azophenyl-2",4"-disulphonic acid (PPADS) abolished the responses to ADPbetaS, and decreased those to ATP, it also depressed the UTP-induced [Ca2+]i transients. adenosine 5'-O-(2-thiodiphosphate) purinergic receptor P2Y1 Homo sapiens