Title : Effects of nicotine on proliferation, cell cycle, and differentiation in immortalized and malignant oral keratinocytes.

Pub. Date : 2005 Aug

PMID : 16011614






2 Functional Relationships(s)
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1 Flow cytometry showed that nicotine inhibited cell cycle progression by inducing G(0)/G(1) arrest of HaCaT, IHOK, HN4, and HN12 cells without causing apoptosis. Nicotine MT-RNR2 like 4 (pseudogene) Homo sapiens
2 Nicotine treatment increased p21 expression in immortalized cells (HaCaT, IHOK) and oral cancer cells (HN4, HN12), but decreased pRb and p53 expression in oral cancer cells. Nicotine MT-RNR2 like 4 (pseudogene) Homo sapiens