Title : Activation of the Ha-, Ki-, and N-ras genes in chemically induced liver tumors from CD-1 mice.

Pub. Date : 1992 Jun 15

PMID : 1596892






1 Functional Relationships(s)
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1 Our results demonstrate that the predominant mutation caused by DMBA in mouse liver tumors is a G to C transversion in Ki-ras codon 13 (DMBA is also known to form guanosine adducts), illustrating the influence of both chemical- and tissue-specific factors in determining the type of ras gene mutations in a tumor. Guanosine Kirsten rat sarcoma viral oncogene homolog Mus musculus