Title : Dopamine, dopamine D2 receptor short isoform, transforming growth factor (TGF)-beta1, and TGF-beta type II receptor interact to inhibit the growth of pituitary lactotropes.

Pub. Date : 2005 Oct

PMID : 15961557






8 Functional Relationships(s)
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1 We found that dopamine and the dopamine agonist bromocriptine stimulated TGFbeta1 secretion and TGFbeta1 mRNA expression but inhibited lactotropic cell proliferation both in vivo and in vitro. Dopamine transforming growth factor beta 1 Gallus gallus
2 We found that dopamine and the dopamine agonist bromocriptine stimulated TGFbeta1 secretion and TGFbeta1 mRNA expression but inhibited lactotropic cell proliferation both in vivo and in vitro. Dopamine transforming growth factor beta 1 Gallus gallus
3 We found that dopamine and the dopamine agonist bromocriptine stimulated TGFbeta1 secretion and TGFbeta1 mRNA expression but inhibited lactotropic cell proliferation both in vivo and in vitro. Dopamine transforming growth factor beta 1 Gallus gallus
4 We found that dopamine and the dopamine agonist bromocriptine stimulated TGFbeta1 secretion and TGFbeta1 mRNA expression but inhibited lactotropic cell proliferation both in vivo and in vitro. Dopamine transforming growth factor beta 1 Gallus gallus
5 We found that dopamine and the dopamine agonist bromocriptine stimulated TGFbeta1 secretion and TGFbeta1 mRNA expression but inhibited lactotropic cell proliferation both in vivo and in vitro. Bromocriptine transforming growth factor beta 1 Gallus gallus
6 We found that dopamine and the dopamine agonist bromocriptine stimulated TGFbeta1 secretion and TGFbeta1 mRNA expression but inhibited lactotropic cell proliferation both in vivo and in vitro. Bromocriptine transforming growth factor beta 1 Gallus gallus
7 The dopamine"s inhibitory action on lactotropic cell proliferation was blocked by a TGFbeta1-neutralizing antibody. Dopamine transforming growth factor beta 1 Gallus gallus
8 These data suggest that a TGFbeta1 system may mediate, in part, the growth-inhibitory action of dopamine on lactotropes. Dopamine transforming growth factor beta 1 Gallus gallus