Pub. Date : 2005 Jun
PMID : 15908192
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we demonstrate that minoxidil treatment of cultured fibroblasts reduces LH1>>LH2b>LH3 mRNA levels dose-and time-dependently, but has essentially no effect on the total number of pyridinoline cross-links in the collagen matrix. | Minoxidil | procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Homo sapiens |
| 2 | These observations can be explained by our finding that LH1 mRNA levels are the most sensitive to minoxidil treatment, corroborating that LH1 has a preference for triple helical lysine residues as substrate. | Minoxidil | procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Homo sapiens |
| 3 | These observations can be explained by our finding that LH1 mRNA levels are the most sensitive to minoxidil treatment, corroborating that LH1 has a preference for triple helical lysine residues as substrate. | Minoxidil | procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Homo sapiens |
| 4 | These observations can be explained by our finding that LH1 mRNA levels are the most sensitive to minoxidil treatment, corroborating that LH1 has a preference for triple helical lysine residues as substrate. | Lysine | procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Homo sapiens |
| 5 | These observations can be explained by our finding that LH1 mRNA levels are the most sensitive to minoxidil treatment, corroborating that LH1 has a preference for triple helical lysine residues as substrate. | Lysine | procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Homo sapiens |
| 6 | In addition, the non-proportional increase in cross-links (20-fold) with respect to the decrease in lysyl hydroxylation state of the triple helix (2-fold) even suggests that LH1 preferentially hydroxylates triple helical lysine residues at the cross-link positions. | Lysine | procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Homo sapiens |
| 7 | We conclude that minoxidil is unlikely to serve as an anti-fibroticum, but confers features to the collagen matrix, which provide insight into the substrate specificity of LH1. | Minoxidil | procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Homo sapiens |