Title : Signaling through Disabled 1 requires phosphoinositide binding.

Pub. Date : 2005 Jun 17

PMID : 15883038






2 Functional Relationships(s)
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1 Within this pathway, Disabled 1 (Dab1) serves as an intracellular adaptor that is tyrosine phosphorylated when Reelin, a secreted glycoprotein, binds to the lipoprotein receptors VLDLR and ApoER2 on the surface of neurons. Tyrosine very low density lipoprotein receptor Homo sapiens
2 Here, we show that the phosphoinositide-binding region within Dab1 PTB domain is required for membrane localization and basal tyrosine phosphorylation of Dab1 independently of VLDLR and ApoER2. Phosphatidylinositols very low density lipoprotein receptor Homo sapiens