Title : Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.

Pub. Date : 2005 Apr 5

PMID : 15784740






1 Functional Relationships(s)
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1 The gene encoding ASPA has been inactivated in the mouse model of CD, and here we show significant decreases in the synthesis of six classes of myelin-associated lipids, as well as reduced acetate levels, in the brains of these mice at the time of peak postnatal CNS myelination. Acetates aspartoacylase Mus musculus