Title : Effects of excipients on the hydrogen peroxide-induced oxidation of methionine residues in granulocyte colony-stimulating factor.

Pub. Date : 2005 Jan

PMID : 15771240






3 Functional Relationships(s)
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1 PURPOSE: The objective of this study was to elucidate the different mechanisms of action of different excipients on the oxidation of Met1, Met122, Met127, and Met138 in granulocyte colony-stimulating factor (G-CSF) by using hydrogen peroxide as the oxidant. Hydrogen Peroxide granzyme M Homo sapiens
2 The efficacy of EDTA on the rates of oxidation of the four methionine residues in G-CSF follows the order Met122 > Met127 > Met138 > Met1. Edetic Acid granzyme M Homo sapiens
3 The efficacy of EDTA on the rates of oxidation of the four methionine residues in G-CSF follows the order Met122 > Met127 > Met138 > Met1. Methionine granzyme M Homo sapiens