Title : Enalapril suppresses normal accumulation of elastin and collagen in cardiovascular tissues of growing rats.

Pub. Date : 1992 Apr

PMID : 1566884






3 Functional Relationships(s)
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1 Enalapril suppresses normal accumulation of elastin and collagen in cardiovascular tissues of growing rats. Enalapril elastin Rattus norvegicus
2 We have investigated the effect of enalapril, an angiotensin converting-enzyme (ACE) inhibitor, on the accumulation of ventricular and vascular collagen and elastin in young, growing rats. Enalapril elastin Rattus norvegicus
3 In contrast, young enalapril-treated animals showed a marked decrease in accumulation of total elastin and collagen in both large (aorta, renal, and carotid) and smaller (superior and large mesenteric) arteries, as well as a large reduction in total collagen in both left and right ventricles. Enalapril elastin Rattus norvegicus