Pub. Date : 2005 Mar
PMID : 15522999
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Memantine caused a concentration-dependent reduction of the amplitudes of whole-cell currents evoked by the alpha7(*) nAChR-selective agonist choline (10 mM) or by N-methyl-d-aspartate (NMDA) (50 muM) plus glycine (10 muM). | Memantine | cholinergic receptor nicotinic beta 1 subunit | Rattus norvegicus |
| 2 | Memantine-induced alpha7(*) nAChR inhibition had an n(H) < 1 and showed a variable voltage dependence; the effect was voltage-independent at 0.1 muM, becoming voltage-dependent at >/=1 muM. | Memantine | cholinergic receptor nicotinic beta 1 subunit | Rattus norvegicus |
| 3 | It is suggested that blockade of alpha7(*) nAChRs by memantine could decrease its effectiveness for treatment of AD, particularly at early stages when the degrees of nAChR dysfunction and of cognitive decline correlate well. | Memantine | cholinergic receptor nicotinic beta 1 subunit | Rattus norvegicus |