Pub. Date : 2004 Nov 9
PMID : 15518554
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography. | CHEMBL163117 | 4-aminobutyrate aminotransferase | Sus scrofa |
| 2 | (1R,3S,4S)-3-Amino-4-fluorocyclopentane-1-carboxylic acid (7) was previously shown to be a mechanism-based inactivator of gamma-aminobutyric acid aminotransferase (GABA-AT) [Qiu, J. and Silverman, R. B. | CHEMBL163117 | 4-aminobutyrate aminotransferase | Sus scrofa |
| 3 | (1R,3S,4S)-3-Amino-4-fluorocyclopentane-1-carboxylic acid (7) was previously shown to be a mechanism-based inactivator of gamma-aminobutyric acid aminotransferase (GABA-AT) [Qiu, J. and Silverman, R. B. | CHEMBL163117 | 4-aminobutyrate aminotransferase | Sus scrofa |
| 4 | Here, a crystal structure of 7 bound to pig liver GABA-AT is reported, which clearly demonstrates that the adduct formed is derived from an enamine mechanism. | cyclopentyl enamine | 4-aminobutyrate aminotransferase | Sus scrofa |